In men, testosterone is a sex hormone that is generated in the testicles, which is a naturally occurring steroid hormone. A little quantity of testosterone is also generated by the ovaries and adrenal glands of a woman.
The hormone testosterone enanthate is used to treat disorders in men and boys that are caused by a deficiency of this hormone, such as delayed puberty, impotence, and other hormonal imbalances. Testosterone enanthate is a prescription medication. This medication is not intended for the treatment of low testosterone that is not caused by specific medical disorders or by becoming older.
Among women, testosterone enanthate is used in the treatment of breast cancer that has spread to other regions of the body (metastatic breast cancer) and cannot be treated with surgery.
The athletic performance will not be improved by the usage of testosterone, and it should not be utilized for this reason.
The medicine Testosterone Enanthate may also be used for other conditions that are not covered in this medication guide.
Testosterone enanthate is sometimes referred to as testosterone heptanoate in certain circles. It is an anabolic androgenic steroid (AAS) medication that is used to treat low testosterone levels in male athletes. Anabolic medications function by increasing muscular mass, whilst androgenic drugs work by improving sex traits that are often associated with men.
Since the 1950s, this medication has been utilized in medical treatments to help patients relax. This medication is recognized by many brand names, including Androfil, Depandro, Testrin, and Testro, and it is only accessible with a doctor’s prescription.
The purpose of this article is to describe how and why the medication is used. It also provides information on side effects and interactions with other medications, as well as answers queries regarding the potential cancer risks associated with taking it.
Testosterone enanthate is a clear or yellowish fluid that comes in a 5-milliliter (ml) glass vial. It is used to increase testosterone levels. It is injected into a buttock muscle every one to four weeks, depending on the individual. Lower dosages administered over shorter periods of time are often utilized to minimize substantial changes in hormone levels and the mood swings that may result as a result of these changes.
The active medication, which is suspended in sesame oil, has a two- to three-week continuous release duration after being administered.
The dose varies from person to person, however, it is commonly administered as follows:
In the case of male hypogonadism, 50 to 400 milligrams (mg) every two to four weeks is recommended.
Delayed male puberty: 5 to 200 mg every two to four weeks for four to six months, repeated every two to four weeks.
Malignancy of the cervix: 200 to 400 mg every two to four weeks in advanced cancer.
Transgender hormone therapy: 50 to 200 mg per week or 100 to 200 mg every two weeks (depending on the dosage regimen).
However, although testosterone enanthate and testosterone cypionate (depo testosterone) are commonly used interchangeably, the latter is only licensed for the treatment of hypogonadism and is not available in the United States.
Testosterone Enanthate is administered in the following ways:
It is normally administered every 2 to 4 weeks, and the injections are made either beneath the skin or into a muscle. Testosterone enanthates should only be administered by a qualified medical expert.
Depending on the problem being treated, the amount of time required for Testosterone Enanthate therapy will vary.
Testosterone has the potential to boost your blood pressure, increasing your chance of having a heart attack, a stroke, or dying. Your blood pressure will need to be monitored on a regular basis. Depending on your situation, you may be required to cease using testosterone or begin taking blood pressure medicine.
You will need to get periodic blood testing.
When males are treated for delayed puberty, testosterone may have an adverse effect on bone development. During therapy, it is possible that x-rays may be required every 6 months to monitor bone formation.
Testosterone Enanthate has the potential to interfere with the findings of some medical tests. Inform any medical professional who treats you that you are taking testosterone.
Male hormone abuse may have serious or permanent consequences, such as swollen breasts and tiny testicles; infertility; high blood pressure; heart attack; stroke; liver illness; bone development difficulties; addiction; and mental side effects including hostility and violence. Theft, sale, or distribution of this medication are all prohibited by law in most countries.
Using too much testosterone may result in unpleasant withdrawal symptoms such as sadness, fatigue, irritability, lack of appetite, sleep disturbances, and a reduction in libido. If you have used too much testosterone, discontinuing the medication may result in these symptoms.
Using testosterone should be avoided if you have prostate cancer, male breast cancer, a major cardiac condition, severe liver or kidney illness, an allergy to castor oil or sesame oil, or if you are pregnant or breastfeeding. Testosterone Enanthate is not intended for use in the treatment of low testosterone that is not caused by a medical condition or by becoming older. It is not recommended to utilize testosterone to improve sports performance.
Testosterone Enanthate should not be used by women who are pregnant or breastfeeding.
Testosterone may raise your chances of having a heart attack, having a stroke, or dying. Depending on your situation, you may be required to cease using testosterone or begin taking blood pressure medicine.
It is possible to have harmful or permanent side effects from the misuse of testosterone. Notify anybody else that you are taking this medication.
Prior to using this medication, you should consult your doctor.
This medication should not be used if you are allergic to testosterone or if you have any of the following conditions:
- Cancer of the breast in men;
- Cancer of the prostate
- Cardiac disorders that are life-threatening;
- Hepatic illness that is serious;
- Renal illness that is severe; or
- Allergy to castor or sesame oil, among other things
Testosterone Enanthate should not be used by women who are pregnant or breastfeeding. This medication has the potential to damage an unborn child.
Inform your doctor if you have ever had any of the following:
- Hypertension (high blood pressure);
- Difficulties with the heart, coronary artery disease (clogging of the arteries);
- Having a heart attack or having a stroke
- Obstructive sleep apnea
- A swollen prostate as well as urinary difficulties
- Cholesterol or triglyceride levels that are excessive;
- Depression, anxiety, a mood disorder, suicidal thoughts
- A large number of red blood cells (RBCs); or
- An illness of the liver or kidneys
The use of testosterone may raise your chance of having prostate cancer, liver difficulties, or heart problems, among other health concerns (including heart attack, stroke, or death). Inquire with your doctor about these dangers.
Women who use testosterone should not breastfeed their children.
An adult should not provide testosterone to a youngster under the age of 12 years. There are several forms of this medication that are not recommended for use by anybody under the age of eighteen.
Certain medical disorders necessitate the use of this medication under no circumstances at all. This includes the use of testosterone in the treatment of untreated prostate cancer or breast cancer, as well as the use of testosterone during pregnancy.
Avoid taking the medication if you are allergic to sesame oil or any of the other components of the medication.
Prostate cancer is a threat.
TRT has been shown to alleviate urinary symptoms associated with benign prostatic hyperplasia (BPH) in men who were born in the male gender.
The prostate gland is a gland found in men who were born into a male gender. Its function is to release prostate fluid, which is one of the components of sperm. It is a common disorder that restricts the flow of urine and may result in bladder stones as well as decreased kidney function.
It is possible that this is not the case for people who are born male but are later diagnosed with prostate cancer. The relationship between testosterone usage and prostate cancer is still up in the air, and there have been cases of testosterone use in older men with untreated prostate cancer resulting in the disease’s progression. Other research has not been able to confirm this.
Although there is still a lot of debate over testosterone usage in men who are not already treated for prostate cancer, the FDA strongly cautions against use.
Even in healthy cis males who do not have prostate cancer, any increase in the prostate-specific antigen (PSA) test during the first three to six months after commencing testosterone would necessitate stopping therapy until a thorough cancer investigation could be conducted.
The dangers of taking testosterone when you have prostate cancer
Male breast cancer is a risk factor
The use of TRT increased the incidence of male breast cancer by 11 percent during a 10-year period, according to research published in 2006. The process by which this relationship is formed is poorly known, and it has not been independently validated.
The FDA maintains its position that testosterone usage constitutes a possible concern to males who have not yet been treated for breast cancer and that it should be avoided at all costs. As a result of the natural conversion (aromatization) of testosterone into estradiol, it is possible to get pregnant.
Pregnancy poses a risk
Testosterone enanthate should not be taken by women who are pregnant or planning to become pregnant. When testosterone is administered to a pregnant woman, it has the potential to harm the baby. Physical traits generally associated with individuals designated male at birth are present in a fetus who was assigned female at birth as a result of this disorder. 1
The presence of some of the symptoms may be evident from birth, while others may not become obvious until adolescence or later in life.
They are as follows:
- Clitoris and external genitals that have grown in size
- Cysts of the ovaries in childhood
- Excessive body or face hair is a problem.
- Bone structure that is more substantial
- Breasts that are smaller
- Male pattern baldness-like hair thinning is a condition that affects men.
- A more hushed tone
- Pregnant women who are suffering virilism as a consequence of testosterone usage have an increased chance of passing on the condition to their unborn children.
If it is suspected that a woman is pregnant, testosterone treatment must be discontinued. This is particularly true during the first trimester of pregnancy. If the pregnancy is confirmed, the parents must be informed of the possible risks to the child’s health and well-being.
Breastfeeding seems to be unaffected by testosterone usage, according to the latest research. The drug’s constituents are substantially broken down before they may enter the circulation, breast milk, or other bodily fluids. High testosterone levels, on the other hand, have been shown to impair milk supply, making nursing unlikely.
Testosterone usage in cis males does not increase the chance of pregnancy, either at conception or over the course of the pregnancy.
Hazards and cautions
Testosterone enanthate has the potential to create major health problems. Depending on the organization, this danger may be significantly greater. If this is a source of concern for you, speak with your doctor or pharmacist about other treatment choices.
Stroke and heart attack dangers
Risk factors include a family history of heart disease.
Testosterone enanthate has the potential to boost your cholesterol levels in the blood, increasing your chance of having a heart attack. In addition, Testosterone enanthate itself has been linked to heart attacks, strokes, and sudden cardiac (heart-related) mortality in certain people. If you have chest discomfort, cold sweats, left arm pain, difficulty breathing, difficulty walking, difficulty speaking, or weakness on one side of your body, notify your healthcare practitioner and get emergency assistance immediately.
Thrombosis (blood clots)
Taking testosterone enanthate has been linked to the formation of blood clots, which may be fatal in the legs and lungs, among other things. Leg discomfort, swelling, and redness are some of the signs and symptoms of a blood clot in the legs. Symptoms of a blood clot in the lungs include trouble breathing as well as chest discomfort. If you have any of these symptoms, notify your physician and seek medical attention immediately, as you may be required to discontinue your prescription.
Abuse, dependence, and addiction are all possibilities.
Risk factors include:
More testosterone enanthate than is recommended | Taking testosterone enanthate in combination with other testosterones
It is illegal to use or possess testosterone enanthate since it has a significant risk of misuse, abuse, and dependence. This is particularly true if you take greater amounts than recommended or combine it with other testosterones. When medication is taken for reasons other than those prescribed, such as sexual dysfunction, this is referred to as misuse. It is considered abuse when the drug is taken for purposes other than those intended by the manufacturer, such as muscle growth or sports performance enhancement. It is possible to suffer from serious heart and mental health problems as a result of testosterone enanthate abuse. These problems include heart attack and heart failure, as well as stroke and liver problems. Depression, delusions, hallucinations, and aggression are also possible side effects of testosterone enanthate abuse. When you become dependent on a medicine and experience withdrawal symptoms, such as depression, sleeplessness, and decreased sex drive, when you reduce the dosage or stop taking the prescription abruptly, you are said to be in a state of dependence on the medication.
The usage of testosterone enanthate may develop into addiction if it is not stopped. It is possible to develop addiction-related behaviors such as taking a higher dose than prescribed, spending a significant amount of time attempting to obtain medication when there is a shortage, prioritizing medication use over other responsibilities, and having difficulty stopping the medication even if you want to stop. Remember to use testosterone enanthate exactly as recommended in order to reduce the danger of misuse, abuse, reliance, and dependence.
Problems with the liver
Risk factors include:
Using large amounts of testosterone enanthate over an extended period of time
Testosterone enanthate has been shown to cause liver damage in animals. Although uncommon, medicine has been linked to the development of liver cancer. If you use large amounts of testosterone enanthate for an extended length of time, you are more prone to develop serious liver issues that may lead to cancer or death. In the event that you are suffering stomach discomfort, light-colored feces, dark urine, or if your skin or the whites of your eyes become yellow, you should contact your healthcare practitioner immediately. You may need to stop taking the prescription. When you quit using testosterone enanthate, you may notice that the yellowing of your skin and the whites of your eyes disappear.
A swollen appearance in the legs or arms (edema)
Risk factors include:
Heart, liver, or renal disease in the family history | Taking other drugs that induce edema, such as corticosteroids, is not recommended.
Taking testosterone enanthate might cause your body to retain more salt and water, which can result in swelling in your legs or arms as well as rapid weight gain, according to some studies. Corticosteroids (such as prednisone and methylprednisolone (Medrol)) and other drugs that induce edema are more likely to have this side effect if you are also taking these medications. The issue may be more dangerous in patients who have heart, liver, and/or renal problems. If you have any of these symptoms, you should see your healthcare practitioner since you may need to discontinue taking your medicine.
Calcium levels in the blood are elevated.
Risk factors include:
Breast cancer survivors | People who have limited mobility | People who are taking other drugs that induce high calcium levels in the blood
Testosterone enanthate, a medicine used to treat breast cancer in women, has been linked to increased calcium levels in the blood. Overconsumption of calcium may result in muscular weakness and renal difficulties, including frequent urination and thirst, stomach discomfort, and the passing of blood via the urine. If this happens, discontinue the use of testosterone enanthate and notify your healthcare professional. It is possible that you may need frequent urine and blood tests while on testosterone enanthate medication to ensure that your calcium levels remain within the usual range.
Children have a rapid bone maturation rate.
Risk factors include:
Long-term use of testosterone enanthate in children | The use of testosterone enanthate in children
Testosterone enanthate should only be given for a limited period of time to treat children who have had delayed puberty. The medicine causes the bones to develop more quickly and to cease increasing in length as a result of this. As a result, if testosterone enanthate is administered for an extended period of time, children may become shorter in height. When it comes to younger children, the likelihood of this occurring is greater. During therapy, your child’s physician may take frequent X-rays of your child’s hand and wrist to ensure that the bones are growing properly.
Allergic responses that be quite severe
Risk factors include:
Allergy to sesame oil is a serious condition.
You should avoid using testosterone enanthate if you are allergic to sesame since the drug includes sesame oil in its formulation. If you have a reaction to this kind of medication, inform your doctor before beginning testosterone enanthate treatment. If you are experiencing hives, a rash, difficulty breathing, or swelling of your face, lips, or throat, call 911 immediately and get medical attention.